{"id":174,"date":"2018-11-01T10:00:51","date_gmt":"2018-11-01T08:00:51","guid":{"rendered":"https:\/\/www.labistanbul.com.tr\/?p=174"},"modified":"2022-07-29T16:51:43","modified_gmt":"2022-07-29T13:51:43","slug":"cerebral-creatinine-deficiency","status":"publish","type":"post","link":"https:\/\/www.labistanbul.com.tr\/en\/cerebral-creatinine-deficiency\/","title":{"rendered":"Cerebral Creatinine Deficiency"},"content":{"rendered":"<h2>Cerebral Creatinine Deficiency Syndromes<\/h2>\n<hr class=\"title-hr\" \/>\n<div class=\"col-sm-12 faq-popular-topics\">\n<div class=\"row\">\n<div class=\"col-sm-12\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>Cerebral creatine deficiency syndromes appear as 3 types.<\/ul>\n<\/li>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><a>Creatine Biosynthesis deficiency (L-arginine-glycine amidinotransferase deficiency \u2013AGAT<\/a><\/li>\n<li><a>Guanidinoacetate Methyltransferase deficiency \u2013GAMT<\/a><\/li>\n<li><a>Creatine transporter deficiency -SLC6A8<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"text-justify\"><strong>Creatine deficiency<\/strong> refers to syndromes, language and speech disorders, epilepsy and mental retardation. In addition, patients with Guanidinoacetate Methyltransferase deficiency or creatine transporter deficiency present with autistic spectrum behaviors.<\/p>\n<p class=\"text-justify\">The common point of these diseases can be detected by in vivo proton magnetic resonance spectroscopy, as well as the depletion of the brain&#8217;s creatine pool. In the diagnosis of the disease, the results of guanidinoacetate, creatine plasma and urine creatinine analysis tests should be evaluated. In line with these findings, some enzyme tests or DNA mutation analysis can be performed.<\/p>\n<p>Since<\/p>\n<p class=\"text-justify\"><strong>Creatine deficiency syndromes<\/strong> are often overlooked in the clinic, they should definitely be considered in cases of unexplained mental retardation, seizures, and speech problems. Guanidinoacetate methyltransferase deficiency and arginine-glycine amidinotransferase deficiency can be treated with creatine supplementation, but patients with creatine transporter deficiency cannot respond to this treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cerebral Creatinine Deficiency Syndromes Cerebral creatine deficiency syndromes appear as 3 types. Creatine Biosynthesis deficiency (L-arginine-glycine amidinotransferase deficiency \u2013AGAT Guanidinoacetate Methyltransferase deficiency \u2013GAMT Creatine transporter deficiency -SLC6A8 Creatine deficiency refers to syndromes, language and speech disorders, epilepsy and mental retardation. In addition, patients with Guanidinoacetate Methyltransferase deficiency or creatine transporter deficiency present with autistic spectrum [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-174","post","type-post","status-publish","format-standard","hentry","category-specific-special-tests"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/posts\/174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/comments?post=174"}],"version-history":[{"count":0,"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/posts\/174\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/media?parent=174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/categories?post=174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.labistanbul.com.tr\/en\/wp-json\/wp\/v2\/tags?post=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}